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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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133 hot topic(s) found with the query "Family health history"

Influence of family history on penetrance of hereditary cancers in a population setting.
Leigh Jackson et al. EClinicalMedicine 2023 11 102159 (Posted: Nov 14, 2023 8AM)

From the abstract: "Women with a pathogenic BRCA1 or BRCA2 variant had an increased risk of breast cancer that was higher in those with a first-degree family history (relative hazard 10.3 and 7.8, respectively) than those without (7.2 and 4.7). Penetrance to age 60 was also higher in those with a family history (44.7%, CI 32.2-59.3 and 24.1%, CI 17.5-32.6) versus those without (22.8%, CI 15.9-32.0 and 17.9%, CI 13.8-23.0). A similar pattern was seen in Lynch syndrome: individuals with a pathogenic MLH1, MSH2 or MSH6 variant had an increased risk of colorectal cancer that was significantly higher in those with a family history (relative hazard 35.6, 48.0 and 9.9) "

Association Between a First-Degree Family History and Self-Reported Personal History of Obesity, Diabetes, and Heart and Blood Conditions: Results From the All of Us Research Program.
Danielle Rasooly et al. J Am Heart Assoc 2023 11 e030779 (Posted: Nov 13, 2023 8PM)

From the abstract: "We assessed the association between a self-reported family history of ODHBs and their risk in the adult population (age =20 years) of the AoU (All of Us) Research Program, a longitudinal cohort study of diverse participants across the United States. We conducted a family history-wide association study to systematically assess the association of a first-degree family history of 15 ODHBs in AoU. We use the FamWAS method to estimate 225 familial associations among 15 ODHBs. The results include overlapping associations between family history of different types of cardiometabolic conditions (such as type 2 diabetes and coronary artery disease), and their risk factors (obesity, hypertension), where adults with a family history of 1 ODHB exhibited 1.1 to 5.6 times (1.5, on average) the odds of having a different ODHB. "

How to Talk to Your Family About Their Heart Health History Even if you’re not super close to your relatives, you’ve got options.
K Miller, Self, September 2023 (Posted: Sep 16, 2023 2PM)

From the website: "If someone in your bio family has heart problems, don’t freak out: It doesn’t mean that you’ll automatically develop them too. Yes, that does increase your risk of developing an issue—but there are loads of other factors that might be meaningful, and this genetic link is just one part of a fuller picture. Bring any information you turn up to a primary care physician first (if you’re not already seeing a specialist): Depending on what you share, your PCP might refer you to a cardiologist who can take a closer look at your overall health, as well as any symptoms that could be indicative of a larger cardiovascular issue. "

Are You Up to Date on Your Preventive Care?
CDC, July 2023 Brand (Posted: Aug 01, 2023 9AM)

Family health history is a record of the diseases and health conditions in your family. You and your family members share genes. You may also have behaviors in common, like what you do for physical activity and what you like to eat. You may live in the same area and come into contact with similar harmful things in the environment. Family history includes all of these factors, any of which can affect your health. If you have a family history of a chronic disease, like cancer, heart disease, diabetes, or osteoporosis, you’re more likely to get that disease yourself.

Family and personal history of cancer in the All of Us research program for precision medicine.
Lauryn Keeler Bruce et al. PLoS One 2023 7 (7) e0288496 (Posted: Jul 18, 2023 2PM)

The All of Us (AoU) Research Program is making available one of the largest and most diverse collections of health data in the US to researchers. Using the All of Us database, we evaluated family and personal histories of five common types of cancer in 89,453 individuals, comparing these data to 24,305 participants from the 2015 National Health Interview Survey (NHIS). Comparing datasets, we found similar family cancer history (33%) rates, but higher personal cancer history in the AoU dataset (9.2% in AoU vs. 5.11% in NHIS).

Talking About Your Family History of Cancer
CDC, July 2023 Brand (Posted: Jul 12, 2023 9AM)

Having open conversations about your family history of cancer can help you and your family members understand your risk for hereditary cancer and make a plan to manage it. Let’s Talk: Sharing Info About Your Family Cancer Risk is an interactive tool to help you learn ways to talk about cancer risk with your family members.

Family history can help identify health risks, but many Latino people know little about theirs
L Medrano, American Heart News, June 2023 (Posted: Jun 30, 2023 10AM)

At the doctor's office, questions about a person's family health history often can help health care professionals determine the risk of developing chronic conditions, including heart disease, high blood pressure and diabetes. But among many Latino people, especially immigrants, talking about and recording family health history is rare. The reasons are not well understood, but studies suggest that cultural influences – family dynamics, stigma, fear and secrecy – can create barriers.

Predicting personal cardiovascular disease risk based on family health history: Development of expert-based family criteria for the general population
T DIjsktra et al, EJHG, March 27, 2023 (Posted: Mar 27, 2023 7AM)

A Delphi procedure carried out in a larger group of expert physicians led to consensus on five family criteria that focus on cardiovascular events at young age (i.e., sudden death, any CVD, implantable cardioverter-defibrillator, aortic aneurysm) and/or an inherited CVD in one or more close relatives. We then applied these family criteria to a high-risk cohort from a clinical genetics department and demonstrated that they have substantial diagnostic accuracy. After further evaluation in a general population cohort, we decided to only use the family criteria for first-degree relatives.

Expanding Family Health History to Include Family Medication History
SB Haga et al, J Per Med, Feb 2023 (Posted: Mar 02, 2023 9AM)

The collection of family health history (FHH) is an essential component of clinical practice and an important piece of data for patient risk assessment. However, family history data have generally been limited to diseases and have not included medication history. Family history was a key component of early pharmacogenetic research, confirming the role of genes in drug response. With the substantial number of known pharmacogenes, many affecting response to commonly prescribed medications, and the availability of clinical pharmacogenetic (PGx) tests and guidelines for interpretation, the collection of family medication history can inform testing decisions.

A Piece of a Puzzle – The All of Us Research Program and Cancer
K Littrell et al, CDC Blog Post, February 27, 2023 Brand (Posted: Feb 27, 2023 9AM)

The All of Us research program has vast potential for making an impact on population health using the new tools of precision medicine. Pairing genomic data with family health history will be critical for clinical utility. The genetic and environmental data that the All of Us research program promises are all important pieces of the puzzle in the progress towards cancer prevention and control.

Increasing Use and Impact of Family Health History in Medically Underserved Populations: Work in Progress
G Wood et al, CDC Blog Post, December 20, 2022 Brand (Posted: Dec 30, 2022 0PM)

Despite years of public health efforts, family health history remains underutilized in clinical care, especially among people who are medically underserved. To address these issues, CDC’s Office of Genomics and Precision Public Health hosted a webinar on November 14, 2022, in conjunction with National Family Health History Day (Thanksgiving). The speakers called for better informed, systematic, and tailored efforts to address inequities in clinical use of FHH

Barriers to family history collection among Spanish-speaking primary care patients: a BRIDGE qualitative study.
Liebermann Erica et al. PEC innovation 2022 1 (Posted: Dec 23, 2022 6PM)

Family history is an important tool for assessing disease risk, and tailoring recommendations for screening and genetic services referral. This study explored barriers to family history collection with Spanish-speaking patients. This qualitative study was conducted in two US healthcare systems. We conducted semi-structured interviews with medical assistants, physicians, and interpreters with experience collecting family history for Spanish-speaking patients.The most common patient-level barrier was the perception that some Spanish-speaking patients had limited knowledge of family history.

Calculating variant penetrance from family history of disease and average family size in population-scale data.
Spargo Thomas P et al. Genome medicine 2022 12 (1) 141 (Posted: Dec 17, 2022 9AM)

We present a method for penetrance estimation in autosomal dominant phenotypes. It examines the distribution of a variant among people affected (cases) and unaffected (controls) by a phenotype within population-scale data and can be operated using cases only by considering family disease history. It is validated through simulation studies and candidate variant-disease case studies.

Implementation-effectiveness trial of systematic family health history based risk assessment and impact on clinical disease prevention and surveillance activities.
Wu R Ryanne et al. BMC health services research 2022 12 (1) 1486 (Posted: Dec 09, 2022 2PM)

19 primary care clinics at four geographically and culturally diverse U.S. healthcare systems. Participants: any English or Spanish-speaking adult with an upcoming appointment at an enrolling clinic. A personal and family health history based HRA with integrated guideline-based clinical decision support (CDS) was completed by each participant prior to their appointment. Risk reports were provided to patients and providers to discuss at their clinical encounter. Systematic health risk assessment revealed that almost half the population were at increased disease risk based on guidelines. Risk identification resulted in shared discussions between participants and providers but variable clinical action uptake depending upon the recommendation.

Hypertrophic Cardiomyopathy (HCM) and Family Health History of Sudden Death
CDC, December 2022 (Posted: Dec 08, 2022 9AM)

If you have a family member, especially a parent, sibling, or child, who died suddenly before age 40, let your doctor know. You might need to be screened for HCM, a genetic condition that causes the heart muscle to become thick and can lead to sudden death. While some people with HCM are very sick, many people, especially children, teens, and young adults, have no or few symptoms and may not know they have a heart problem. Sharing your family history with your doctor can help you and other relatives find HCM early.

Systematic comparison of family history and polygenic risk across 24 common diseases.
Mars Nina et al. American journal of human genetics 2022 11 (Posted: Nov 10, 2022 6AM)

Covering a large proportion of the burden of non-communicable diseases in adults, we show that family history and PRS are independent and not interchangeable measures, but instead provide complementary information on inherited disease susceptibility. The PRSs explained on average 10% of the effect of first-degree family history, and first-degree family history 3% of PRSs, and PRS effects were independent of both early- and late-onset family history. The PRS stratified the risk similarly in individuals with and without family history.

When It Comes to Breast Cancer, Sometimes It’s All in the Family
G Miller, CDC Cancer, Blog, October 2022 Brand (Posted: Oct 28, 2022 9AM)

Has anyone ever told you that you have your mother’s eyes? Or that you look just like your grandmother? We all get our looks and physical traits from our families, but we may not always think about risks we share for diseases like cancer, including breast cancer. The good news is that knowing your family cancer history can give you a head start toward preventing breast cancer. No matter your gender, it’s important to know your risk and learn how to protect yourself.

The Joint Public Health Impact of Family History of Diabetes and Cardiovascular Disease among Adults in the United States: A Population-Based Study
D Rasooly et al, Public Health Genomics, October 6, 2022 (Posted: Oct 06, 2022 1PM)

Participants with joint family history exhibit 6.5 greater odds for having both diseases and are diagnosed with diabetes 6.6 years earlier than participants without family history. Healthy participants without prevalent CVD or diabetes but with joint family history exhibit a greater prevalence of diabetes risk factors compared to no family history counterparts. Joint family history is associated with an increase in all-cause mortality. Over 44% of the US adult population has a family history of CVD and/or diabetes. This wide presence of high-risk family history suggests that clinical and public health efforts should collect and act on joint family history of CVD and diabetes to improve population efforts in the prevention and early detection of these common chronic diseases.

FHH Quick App Review: How Can a Quality Review Process Assist Primary Care Providers in Choosing a Family Health History App for Patient Care?
GM Wood et al, Genes, August 2022 (Posted: Aug 25, 2022 1PM)

Family health history (FHH) is a data type serving risk assessment, diagnosis, research, and preventive health. Despite technological leaps in genomic variant detection, FHH remains the most accessible, least expensive, and most practical assessment tool for assessing risks attributable to genetic inheritance. The purpose of this manuscript is to outline a process to assist primary care professionals in choosing FHH digital tools for patient care based on the new ISO/TS 82304-2 Technical Specification (TS), which is a recently developed method to determine eHealth app quality.

Why Family Health History is Important if You or Your Child has Learning or Attention Problems
CDC, June 13, 2022 (Posted: Jun 13, 2022 3PM)

Difficulties with learning and attention can run in families. Knowing about this family health history can help your child’s health care provider make a diagnosis if your child is having difficulty with learning or attention. Having a family member, especially another child, with a learning or attention problem can help you identify concerns early in your child. Finding learning and attention disorders early can help your child get services sooner, which can help your child succeed. Finding out more about family health history can help some parents discover for the first time that they also have a learning disorder or ADHD that has not been diagnosed or treated. However, having family members with learning or attention disorders does not automatically mean that your child will have a problem with learning or attention.

Family history tools for primary care: A systematic review.
Miroševic Špela et al. The European journal of general practice 2022 28(1) 75-86 (Posted: May 10, 2022 8AM)

This review explores the FH tools currently available for PC and evaluates their clinical performance.Five databases were systematically searched until May 2021. Identified tools were evaluated on the following criteria: time-to-complete, integration with electronic health record (EMR) systems, patient administration, risk-assessment ability, evidence-based management recommendations, analytical and clinical validity and clinical utility.We identified 26?PC FH tools. Analytical and clinical validity was poorly reported and agreement between FH and gold standard was commonly inadequately reported and assessed. Sensitivity was acceptable; specificity was found in half of the reviewed tools to be poor. Most reviewed tools showed a capacity to successfully identify individuals with increased risk of disease (6.2-84.6% of high and/or moderate or increased risk individuals).Despite the potential of FH tools to improve risk stratification of patients in PC, clinical performance of current tools remains limited as well as their integration in EMR systems. Twenty-one FH tools are designed to be self-administered by patients.

Increased family history documentation in internal medicine resident continuity clinic at a community hospital through resident-led structured genetic education program.
Chenbhanich Jirat et al. Journal of community genetics 2022 (Posted: Mar 05, 2022 7AM)

FH documentation in EMR was reviewed and compared to a 4-week baseline (Phase 0). We found that time constraint was the most reported barrier. We reviewed 1197 patient visits; FH was recorded in 34% (67/200), 52% (272/522), and 50% (239/475) during Phase 0, Phase1, and Phase 2, respectively. Genetic education significantly increased the rate of FH documentation in Phase 1 from baseline, which was maintained in Phase 2 despite removal of interventions. The mean age of patients with documented FH was younger than those without documentation (48 years vs 51 years; p?<?0.001). Documented FH of cancers and coronary artery disease lacked important details, such as age at diagnosis, in 62% (86/138) and 51% (41/81) of them, respectively. Out of 511 patients that had documented FH, we identified 66 patients (13%) where positive family history could alter medical management

Self-rated family health history knowledge among All of Us program participants
LE Hull et al, Genetics in Medicine, January 17, 2022 (Posted: Jan 18, 2022 8AM)

We performed a cross-sectional analysis of survey data from the All of Us Research Program. Self-rated family health history data were available for 116,799 participants. Most survey participants (63%) had no or some knowledge about their family health history (n = 43,661). Associated factors included assigned male sex at birth, gender and sexual minorities, self-reported race other than White, lower household annual income (<$25,000), or lower educational attainment (<high school graduate).

Why Knowing Your Family’s Health Past Benefits Your Future
L Orlando, Duke University, November 2021 (Posted: Nov 23, 2021 8AM)

Knowing your family’s health history is one of the most important ways to maintain your health. It can be some of the best information doctors have to understand your risk for developing medical conditions. If you’re seeing family this holiday season, it’s a great time to talk about their past treatments and current medical needs. Asking questions about what’s impacted your loved ones will give you a more complete picture of how your own health may change in the future -- and how your doctor can help.

Stay Informed of Your Family Health History
CDC Public Health Matters Blog, November 22, 2021 Brand (Posted: Nov 22, 2021 11AM)

Thanksgiving Day is National Family Health History Day. Family health history is a record of the diseases and health conditions in your family. Most people have family history of at least one chronic disease that makes them more likely to get that disease. Staying informed of your family’s health history can help you and your doctor prepare for and prevent diseases you are more likely to get and that can affect you later in life.

Happy Thanksgiving 2021! Family Health History in the COVID-19 Era
RF Green et al, CDC Blog Post, November 16, 2021 Brand (Posted: Nov 16, 2021 8AM)

For a second year in a row, this Thanksgiving might not look the same as the ones before it, but some things haven’t changed. Even if you can’t see your loved ones in person, Thanksgiving is still a great time to talk to your family members about your family health history. Having one or more family members with a disease can mean that you and others in the family are more likely to get that disease. But it’s not inevitable — for many chronic diseases, knowing about your family health history can empower you to take steps that make you less likely to get diseases that run in your family.

Family Health History Social Media Campaign
NHGRI, November 2021 (Posted: Nov 11, 2021 2PM)

November is Family Health History Awareness Month! To celebrate, the National Human Genome Research Institute will host several engagement events over social media on Wednesday, November 17. We encourage you and your organizations to join in and help amplify our Institute’s mission to increase genomic literacy and family health history awareness.

Evaluating Primary Care Providers' Readiness for Delivering Genetic and Genomic Services to Underserved Populations.
Sharma Yashoda et al. Public health genomics 2021 1-10 (Posted: Sep 17, 2021 6AM)

We evaluated the readiness of primary care providers at a Federally Qualified Health Center, the Community Health Center, Inc. (CHCI) for delivering genetic and genomic testing to underserved populations. Online survey questions focused on providers' education and training in basic and clinical genetics, familiarity with current genetic tests, and needs for incorporating genetics and genomics into their current practice.Fifty of 77 (65%) primary care providers responded to the survey. Less than half received any training in basic or clinical genetics (40%), were familiar with specific genetic tests (36%), or felt confident with collecting family health history (44%), and 70% believed patients would benefit from genetic testing.Despite knowledge gaps, respondents recognized the value and need to bring these services to their patients.

Mapping Users' Experience of a Family History and Genetic Risk Algorithm Tool in Primary Care.
Miroševic Špela et al. Public health genomics 2021 1-10 (Posted: Sep 17, 2021 6AM)

Importance of Family History of Colorectal Cancer In Situ Versus Invasive Colorectal Cancer: A Nationwide Cohort Study.
Tian Yu et al. Journal of the National Comprehensive Cancer Network : JNCCN 2021 1-6 (Posted: Sep 17, 2021 6AM)

Reinvigorating Family Health History in the Era of Genomics
CDC Webinar, November 18, 2021 Brand (Posted: Sep 12, 2021 5PM)

This seminar will address current efforts to improve data collection on family health history from consumers and clinicians and how this information can be added to electronic medical records. Speakers will discuss how public health can address the growing need for guidance as clinicians and consumers struggle with how to implement genomics into clinical care and highlight international family health history efforts.

Resources in Genomics and Precision Health to Enhance Public Health Impact of New Technologies
CDC slide set, 2021 Brand (Posted: Jul 19, 2021 2PM)

The presentation reviews the CDC Public Health Genomics and Precision Health Knowledge Base (PHGKB), a suite of searchable databases that includes publications and other resources. It includes: 1) COVID Genomics and Precision Health, a database that includes publications and other resources about the impact of genomics and precision health technologies on the investigation and control of COVID-19; 2) My Family Health Portrait, a family health history collection tool that allows users to save and share their family health history information; and 3) Specialized PHGKB databases such as reproductive and child health, family health history, and health equity.

MFHP Cancer
CDC, July 2021 (Posted: Jul 11, 2021 2PM)

Use the app to collect your family history of cancer and determine your risk for breast, ovarian and/or colorectal cancer. You can view your risk factors and learn about what to do next. You will also be able to see your family's history of cancer in a family tree.

An Evaluation of “My Family Health Portrait”: Strengths and Opportunities
D Yu et al, CDC Blog, June 22, 2021 Brand (Posted: Jun 23, 2021 8AM)

CDC has hosted My Family Health Portrait (MFHP) since September 2018. Understanding current use of MFHP can help identify opportunities to improve and promote MFHP. We used Google Analytics to explore use of MFHP from Jan 1, 2019 to Dec 31, 2020. Google Analytics is a third-party tool that tracks user information, such as browser, language, screen resolution, and, in some cases, location, age, and gender.

Modernizing family health history: achievable strategies to reduce implementation gaps.
Wildin Robert S et al. Journal of community genetics 2021 (Posted: May 28, 2021 4PM)

The NHGRI Family Health History Group, an open-membership, US-based group with international members, believes that integrating FHH in healthcare and research is more important than ever, and that achievable implementation advances, including education, are urgently needed to boost the pace of translational utility in genomic medicine. An inventory of implementation gaps and proposed achievable strategies to address them, representing a consensus developed in meetings from 2019-2020, is presented here. The proposed measures are diverse, interdisciplinary, and are guided by experience and ongoing implementation and research efforts.

A Hybrid Model for Family History Information Identification and Relation Extraction: Development and Evaluation of an End-to-End Information Extraction System.
Kim Youngjun et al. JMIR medical informatics 2021 9(4) e22797 (Posted: Apr 27, 2021 9AM)

Family history information is important to assess the risk of inherited medical conditions. Natural language processing has the potential to extract this information from unstructured free-text notes to improve patient care and decision making. We describe the end-to-end information extraction system the Medical University of South Carolina team developed when participating in the 2019 National Natural Language Processing Clinical Challenge (n2c2)/Open Health Natural Language Processing (OHNLP) shared task.

Risk Factors for Syncope Associated With Multigenerational Relatives With a History of Syncope
A Fedorowski et al, JAMA Network Open, March 30, 2021 (Posted: Mar 31, 2021 8AM)

In this population-based cohort study among adults in Sweden, family history of syncope was associated with increased incidence of syncope, and the familial risk was associated with genetic resemblance and age.

Clinical implementation of an oncology-specific family health history risk assessment tool.
Fung Si Ming et al. Hereditary cancer in clinical practice 2021 19(1) 20 (Posted: Mar 26, 2021 9AM)

Utility of a virtual counselor (VICKY) to collect family health histories among vulnerable patient populations: A randomized controlled trial.
Wang Catharine et al. Patient education and counseling 2021 (Posted: Mar 26, 2021 9AM)

A virtual counselor overcomes many of the literacy-related barriers to using traditional digital tools and highlights an approach that may be important to consider when collecting health histories from vulnerable populations. The usability of digital health history tools will have important implications for the quality of the data collected and its downstream clinical utility.

Autism Spectrum Disorder, Family Health History, and Genetics
CDC, March 2021 Brand (Posted: Mar 25, 2021 8AM)

If someone in your family has autism spectrum disorder (ASD), you may be more likely to have a child with ASD. ASD can look very different from person to person, so taking a careful family health history can be important for early diagnosis. Early screening and diagnosis of ASD can ensure that children receive the services they need for better outcomes.

The Value of Family History in Colorectal Screening Decisions for Oldest Old Geriatric Populations.
Miller David R et al. Cureus 2021 13(1) e12815 (Posted: Mar 02, 2021 9AM)

Risk-adapted starting age of breast cancer screening in women with a family history of ovarian or other cancers: A nationwide cohort study.
Mukama Trasias et al. Cancer 2021 (Posted: Feb 26, 2021 11AM)

Family history assessment significantly enhances delivery of precision medicine in the genomics era.
Bylstra Yasmin et al. Genome medicine 2021 Jan (1) 3 (Posted: Jan 09, 2021 0PM)

This study demonstrates that the collection and analysis of comprehensive family history and genomic data are complementary and in combination can prioritize individuals for genomic analysis. Thus, family history remains a critical component of health risk assessment, providing important actionable data when implementing genomics screening programs.

Family Health History PHGKB
CDC, November 2020 Brand (Posted: Nov 25, 2020 9AM)

Family Health History PHGKB is an online, continuously updated, searchable database of information and publications relevant to the role of family health history in healthcare and disease prevention.

Happy Thanksgiving 2020: Family and Family Health History Are As Important As Ever
RF Green et al, November 23, 2020 Brand (Posted: Nov 24, 2020 1PM)

This Thanksgiving might not look the same as the ones before it, but some things haven’t changed. Even if you can’t see your loved ones in person, Thanksgiving is still a great time to talk to your family members about your family health history.

Family Health History for Healthcare Professionals
NHGRI, November 2020 (Posted: Nov 17, 2020 9AM)

Family health history is a record of the diseases and health conditions in your family. Knowing the health history of your family members can help you and your healthcare providers determine how to manage your health and the health of your family.

Family Health History for Patients and Families
NHGRI, November 2020 Brand (Posted: Nov 17, 2020 9AM)

Find out how learning your family's health history can help you discover your genomic heritage and risks, and guide you in making healthy environment and lifestyle choices.

The Family Health History Group
NHGRI, October 2020 Brand (Posted: Oct 05, 2020 3PM)

The group connects stakeholders, researchers, and thought leaders to share learning, understand barriers, and discuss issues and potential solutions related to collection of family health history information. Multidisciplinary members come from government, industry, health care, research, advocacy, and policy backgrounds, and represent many countries.

Revisiting the Roles of Primary Care Clinicians in Genetic Medicine.
Hull Leland E et al. JAMA 2020 Sep (Posted: Sep 25, 2020 9AM)

This Viewpoint highlights 4 approaches to facilitate genetics care for patients: (1) capturing and updating a family health history; (2) initiating testing and diagnostic workup for some genetic conditions; (3) recognizing indications for referral to subspecialists with genetics expertise; and (4) sharing management of surveillance for patients with specialists.

Family history misses identifying individuals with high genetic risk of CVD or cancer
Mass General Hospital, May 1, 2020 (Posted: May 03, 2020 7AM)

"What was really striking was that simply taking a family history--as I currently do in my clinical practice--would have failed to identify most of the high-risk individuals"

The enduring importance of family health history in the era of genomic medicine and risk assessment.
Haga Susanne B et al. Personalized medicine 2020 Apr (Posted: Apr 29, 2020 7AM)

Is family history of coronary artery disease important in the emergency department triage?
Mor Saban et al. International emergency nursing 2020 Mar 100855 (Posted: Apr 08, 2020 9AM)

Evaluation of family health history collection methods impact on data and risk assessment outcomes.
Wu R Ryanne et al. Preventive medicine reports 2020 Jun 18101072 (Posted: Mar 25, 2020 9AM)

What Is Colorectal Cancer Screening?
CDC, March 2020 Brand (Posted: Mar 09, 2020 8AM)

Regular screening, beginning at age 50, is the key to preventing colorectal cancer. If you think you may be at increased risk for colorectal cancer, learn your family health history and ask your doctor if you should begin screening before age 50.

Heart Disease Family Health History, and Familial Hypercholesterolemia
CDC, March 2020 Brand (Posted: Mar 05, 2020 8AM)

Having a family health history of heart disease makes you more likely to develop heart disease yourself. In some cases, having family members with heart disease at a young age (age 50 or younger) can be a sign of familial hypercholesterolemia, a genetic disease that causes high cholesterol. Take time to collect your family health history of heart disease.

Family History of Gastric Cancer and Helicobacter pylori Treatment.
Choi Il Ju et al. The New England journal of medicine 2020 Jan (5) 427-436 (Posted: Jan 30, 2020 9AM)

Among persons with H. pylori infection who had a family history of gastric cancer in first-degree relatives, H. pylori eradication treatment reduced the risk of gastric cancer.

Evidence for penetrance in patients without a family history of disease: a systematic review.
Turner Heather et al. European journal of human genetics : EJHG 2020 Jan (Posted: Jan 16, 2020 8AM)

It is evident from the findings that the evidence base for penetrance estimates in individuals without a family history of disease is limited. Future work is needed to refine design of penetrance studies and the impact of incorrect estimates.

Designing and Evaluating a Digital Family Health History Tool for Spanish Speakers.
Cerda Diez Maria et al. International journal of environmental research and public health 2019 Dec 16(24) (Posted: Dec 18, 2019 8AM)

Spanish VICKY may be useful as a tool to collect family health history and was viewed as acceptable and usable. The study results shed light on some cultural differences that may influence interactions with family history tools and inform future research aimed at designing and testing culturally and linguistically diverse digital systems.

If a Family Member Has Alzheimer's Disease, Will I Have It, Too?
NIH, 2019 Brand (Posted: Nov 19, 2019 8AM)

Learning about your family health history may help you know if you are at increased risk for certain diseases or medical conditions, like Alzheimer's disease. Share this infographic and help spread the word about Alzheimer's genetics.

The Public Health Family Impact Checklist: A Tool to Help Practitioners Think Family
A Crandall et al, Frontiers in Public Health, November 2019 (Posted: Nov 13, 2019 8AM)

To improve population health, public health programs must support families. Limited training in family science, as well as lack of instruments to help “think family,” often result in Public Health practitioners feeling ill-equipped to develop programming that supports, targets, and/or involves a diverse range of families.

Family History and Heart Disease
NIDDK podcast, November 11, 2019 (Posted: Nov 12, 2019 8AM)

Heart disease is the number one cause of death for men and women. And if you have a family history of heart disease that may put you at a greater risk. Your risk increases if a close relative was diagnosed with heart disease, especially if it was before the age of 55 in your father or brother, or before the age of 65 if it was your mother or a sister.

Family Health History: The First Genetic Test in Precision Medicine.
Bennett Robin L et al. The Medical clinics of North America 2019 Nov 103(6) 957-966 (Posted: Oct 09, 2019 8AM)

The collection of family history has always been a tool for genetic evaluation, but it remains an essential tool even in the age of genomic medicine. Patients may have a risk for a disease based on family history regardless of the results of genetic and genomic tests.

Family Health History Quiz
NIDDK, 2019 Brand (Posted: Sep 30, 2019 8AM)

The National Diabetes Education Program encourages all families to take advantage of family gatherings to share information about their health history - especially when it comes to diabetes. Knowing your family health history is important because it gives you and your health care team information about your risk for type 2 diabetes and other health problems.

11 Tips for a Healthy Fall
CDC, September 2019 Brand (Posted: Sep 23, 2019 10AM)

11 tips include: Learn Your Family Health History: Knowing and acting on your family health history is an important way to protect your health. Collect your family health history and share it with your doctor at your next visit. Your doctor can use it to develop a more complete picture of your health and your risk factors for disease.

Genetic Counseling and Public Health in the Era of Precision Medicine
MJ Khoury, CDC Blog, September 18, 2019 Brand (Posted: Sep 19, 2019 9AM)

As more genetic counselors make a leap from individual patient care to population health concerns including implementation and disparities, genetic counselors will help enhance the public’s genetic awareness and literacy about genomics and family health history, contribute to policy, evaluation and implementation, and drive the overall success of genomic medicine.

Get familiar with your family health history,
Fox 16, July 15, 2019 (Posted: Jul 17, 2019 8AM)

If a relative had diabetes, heart disease or cancer, that doesnâ??t mean youâ??ll definitely get it too. Other things besides genesâ??like our health habits and environmentâ??matter as well. But itâ??s better to know if thereâ??s a chance you may be at higher risk. That way, you can take steps to lower your risk or find the condition early, when it may be easier to treat. For example, if certain diseases run in your family, your doctor may want you to get screened for them earlier or more often than usual.

Patterns of Communicating About Family Health History: Exploring Differences in Family Types, Age, and Sex.
Campbell-Salome Gemme et al. Health education & behavior : the official publication of the Society for Public Health Education 2019 Jun 1090198119853002 (Posted: Jun 26, 2019 9AM)

This study of more than 200 participants examined the direct and indirect effects of family communicative environments on whether individuals actively collected FHH information, as well as how age and sex differences complicate this relationship. Results show there was a direct effect between open family communicative environments and active collection, and found FHH communication openness was a positive partial mediator

Factors Influencing Not Perceiving Family Health History Assessments as Important: Opportunities to Improve Dissemination of Evidence-Based Population Screening for Cancer
CG Allen et al, Public Health Genomics, May 2019 (Posted: May 05, 2019 11AM)

Researchers build a statistical model using family health history to improve disease risk assessment
P Ganguly, NHGRI, May 1, 2019 Brand (Posted: May 02, 2019 8AM)

Factors Influencing Not Perceiving Family Health History Assessments as Important: Opportunities to Improve Dissemination of Evidence-Based Population Screening for Cancer.
Allen Caitlin G et al. Public health genomics 2019 Apr 1-10 (Posted: Apr 17, 2019 9AM)

Breast cancer study confirms importance of multigenerational family data to assess risk
Eureka Alert, Columbia University, School of Public helath, February 21, 2019 (Posted: Feb 24, 2019 1PM)

Population-based Relative Risks for Specific Family History Constellations of Breast Cancer
FS Albright et al, BioRXIV, January 2019 (Posted: Jan 08, 2019 8AM)

New Year, New Healthy You
9 tips to boost your health and well-being all year long include knowing your family health history. December 2018 Brand (Posted: Dec 29, 2018 0PM)

The value of genetic testing for family health history of adopted persons.
May Thomas et al. Nature reviews. Genetics 2018 Nov (Posted: Dec 02, 2018 10AM)

Happy Thanksgiving 2018: Update and Act on Your Family Health History!
MJ Khoury, CDC Blog Post, November 19, 2018 Brand (Posted: Nov 19, 2018 1PM)

Adoptees lacking family health history look to whole genome sequencing for answers
M Thomas, Hudson Alpha, October 2018 (Posted: Oct 26, 2018 11AM)

Adoptees' Pursuit of Genomic Testing to Fill Gaps in Family Health History and Reduce Healthcare Disparity.
Casas Kari A et al. Narrative inquiry in bioethics 2018 8(2) 131-135 (Posted: Sep 19, 2018 9AM)

Announcing a New CDC Home for the U.S. Surgeon General’s Family Health History Tool
MJ Khoury, LL Rodriguez, CDC Blog Post, September 6, 2018 Brand (Posted: Sep 06, 2018 6PM)

My Family Health Portrait: A Tool from The Surgeon General
Public Health Genomics Knowledge Base, September 6, 2018 Brand (Posted: Sep 06, 2018 6PM)

Family health history and genetic services-the East Baltimore community stakeholder interview project.
Sanghavi Kunal et al. Journal of community genetics 2018 Aug (Posted: Sep 05, 2018 9AM)

Know Your Body. Know Your Family History.
Sun Hee Rim et al, CDC Blog, August 2018 Brand (Posted: Sep 03, 2018 9AM)

Family History and Cancer
CDC Division of Cancer Control and Prevention, 2018 Brand (Posted: Sep 03, 2018 9AM)

Early Detection Sparks Swift Treatment for Brain Aneurysm
Mayo Clinic, August 2018 (Posted: Aug 27, 2018 8AM)

What characterizes cancer family history collection tools? A critical literature review.
Cleophat J E et al. Current oncology (Toronto, Ont.) 2018 Aug 25(4) e335-e350 (Posted: Aug 22, 2018 11AM)

Family History of Cardiovascular Disease: How Detailed Should It Be?
Bittencourt Márcio Sommer et al. Mayo Clinic proceedings 2018 Aug (Posted: Aug 15, 2018 10AM)

Why is it important to know my family medical history?
National Library of Medicine, Genetics Home Reference, July 2018 Brand (Posted: Jul 24, 2018 9AM)

Implementation, adoption, and utility of family health history risk assessment in diverse care settings: evaluating implementation processes and impact with an implementation framework.
Wu R Ryanne et al. Genetics in medicine : official journal of the American College of Medical Genetics 2018 Jun (Posted: Jun 11, 2018 11AM)

An open-source, integrated pedigree data management and visualization tool for genetic epidemiology.
Ranaweera Thilina et al. International journal of epidemiology 2018 Apr (Posted: May 29, 2018 0PM)

Basic vs More Complex Definitions of Family History in the Prediction of Coronary Heart Disease: The Multi-Ethnic Study of Atherosclerosis
J Patel et al, Mayo Clin Proc, May 2018 (Posted: May 26, 2018 9AM)

Family trees hidden in medical records could predict your disease risk
J Kaiser, Science, May 17, 208 (Posted: May 18, 2018 8AM)

Disease Heritability Inferred from Familial Relationships Reported in Medical Records
FCG Polubriaginof et al Cell, May 18, 2018 (Posted: May 18, 2018 8AM)

Investigation of the Use of a Family Health History Application in Genetic Counseling.
Tipsword Meghan L et al. Journal of genetic counseling 2017 Dec (Posted: Dec 26, 2017 9AM)

Happy Thanksgiving 2017: Take time to collect, share, and act on your family health history, it may save your life!
MJ Khoury, Blog Post, November 20, 2017 Brand (Posted: Nov 20, 2017 9PM)

Knowing is Not Enough—Act on Your Family Health History
Brand (Posted: Nov 20, 2017 9PM)

Family Health History and Diabetes
Brand (Posted: Jun 11, 2017 1PM)

Family Health History During Pregnancy
Brand (Posted: May 07, 2017 1PM)

Family Health History and Planning for Pregnancy
Brand (Posted: May 07, 2017 1PM)

Does Lack of "Genetic-Relative Family Health History" Represent a Potentially Avoidable Health Disparity for Adoptees?
May Thomas et al. The American journal of bioethics : AJOB 2016 Dec 16(12) 33-38 (Posted: Dec 07, 2016 9AM)

Family Health History
New CDC Resources Across the Life Span Brand (Posted: Oct 21, 2016 11AM)

Webinar: Cancer and Family History- Information you need to assess your risk
NSGC, November 2, 2016 (Posted: Oct 21, 2016 11AM)

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Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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